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Lithium Induces Apoptosis in Immature Cerebellar Granule Cells but Promotes Survival of Mature Neurons

✍ Scribed by Santosh R. D'Mello; Roberta Anelli; Pietro Calissano

Book ID
115601701
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
731 KB
Volume
211
Category
Article
ISSN
0014-4827

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Cerebellar granule neurons isolated from 7-day-old rats and cultured in normal medium undergo apoptosis, but remain healthy under depolarizing conditions with elevated K Ψ‰ (ΠΌ25 mM) or in the presence of brain-derived neurotrophic factor. Northern blot analysis showed that cyclin D1 mRNA was upregula