Lithium and anticholinergic combination to maintain a stable lithium plasma level

✍ Scribed by S. Eralp Bellibas; Sibel Ülker; Kazim Akfert; Professor Dr Isik Tuglular; Simavi Vahip

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 285 KB
• Volume: 9
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.470090104

✦ Synopsis

The effect of lithium and propantheline, an anticholinergic agent, combination on plasma and red blood cell (RBC) lithium levels was studied to test if this combination could maintain a stable plasma lithium level for a long-lasting period by delaying gastric emptying, in rabbits. There was a significant difference in plasma lithium levels between control and propantheline-administered groups (p < 0-01). The peak level seen in the second hour of lithium administration in the control group was not observed in the propantheline-administered group and a stable lithium level was maintained. It was suggested that a lithium and anticholinergic drug combination can be an alternative in eliminating the peak plasma levels of lithium and preventing the side-effects thought to be related to this factor.