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Lithium and amphetamine: Opposite effects on threshold of intracranial reinforcement

โœ Scribed by Geraldine Pick Cassens; A. William Mills

Publisher
Springer
Year
1973
Tongue
English
Weight
506 KB
Volume
30
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

The effects of lithium chloride on the behavior of rats aroused by electrical self-stimulation of the brain were compared to the effects of a known stimulant, d-amphetamine sulfate. The threshould of the reinforcing effect of this same electrical stimulation was determined by a classical psychophysical method. A threshold of reinforcement was defined by counting the postreinforcement pauses during concurrent fixed-ratio and continuous reinforcement schedules. Lithium raises and d-amphetamine lowers this threshold. These threshold changes correspond to the opponent behavioral and biochemical actions produced by these drugs in man.

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