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Lithium Ameliorates HIV-gp120-Mediated Neurotoxicity

โœ Scribed by Ian P. Everall; Christopher Bell; Margaret Mallory; Dianne Langford; Anthony Adame; Edward Rockestein; Eliezer Masliah


Book ID
115637922
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
438 KB
Volume
21
Category
Article
ISSN
1044-7431

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The viral coat of the HIV-1 virus, gp120, has been shown to cross the blood-brain barrier (BBB) in lectin-like fashion by inducing adsorptive endocytosis (AE), a vesicular mechanism that could provide pathways into and across brain endothelial cells for virus and infected immune cells. Here, we exte