Study of the lithiation of 3-substituted
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Cyril Papamicaël; Georges Dupas; Jean Bourguignon; Guy Quéguiner
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Article
📅
1994
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Elsevier Science
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French
⚖ 329 KB
The synthesis of new 3-substituted a-carbolines is described and these products were subjected to ortho-lithiation experiments. 3-pivalamido and 3-carboxamido derivatives are cleanly lithiated at 4position. The results are correlated with MNDO calculations. Various 3,4-disubstituted a-carbolines are