Lisinopril has no natriuretic effect in elderly: A study of the single-dose response in aged vs young individuals
✍ Scribed by Dominique Chevet; Jean-Pierre Mallie; Claude Jeandel
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 403 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0924-8455
No coin nor oath required. For personal study only.
✦ Synopsis
In order to evaluate the short-term effect of anglo-converting-enzyme (ACE) inhibition on the renal water and electrolyte handling in healthy elderly, we compared the actions of a single oral dose of lisinopril (Prinivil, 20 mg) in 13 healthy individuals over 75 years of age (82.6 + 5.8 yrs) with that of 6 healthy young subjects (26.2 + 0.7 yrs). No variations in serum sodium were observed in either groups. In the young group, we observed an increase in sodium excretion and glomerular filtration rates (creatinine clearance). In the aged group, we did not find any increase in sodium excretion and GFR remained unchanged, while diuresis decreased. The possible mechanisms for this discrepancy are discussed. The aged kidney submitted to ACE inhibition reacts in a different way than the younger kidney and this could lead, at least theoretically, to sodium retention. The therapeutic use of ACE inhibitors should be carefully monitored when a natriuretic effect is required.