Liquid–liquid miscibility gaps and hydrate formation in drug–water binary systems: Pressure–temperature phase diagram of lidocaine and pressure–temperature–composition phase diagram of the lidocaine–water system
✍ Scribed by René Ceolin; Maria Barrio; Josep-Lluis Tamarit; Nestor Veglio; Marc-Antoine Perrin; Philippe Espeau
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 388 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The pressure-temperature (P-T) melting curve of lidocaine was determined (dP/dT = 3.56 MPa K(-1)), and the lidocaine-water system was investigated as a function of temperature and pressure. The lidocaine-water system exhibits a monotectic equilibrium at 321 K (ordinary pressure) whose temperature increases as the pressure increases until the two liquids become miscible. A hydrate, unstable at ordinary pressure, was shown to form, on increasing the pressure, from about 70 MPa at low temperatures (200-300 K). The thermodynamic conditions of its stability were inferred from the location of the three-phase equilibria involving the hydrate in the lidocaine-water pressure-temperature-mole fraction (P-T-x) diagram.