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Liquid-phase combinatorial reaction monitoring by conventional 1H NMR spectroscopy

✍ Scribed by Jing-Ying Shey; Chung-Ming Sun


Book ID
104250488
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
123 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


The application of 1 H NMR spectroscopy for complete analysis of soluble polymer-supported reactions is described. This conventional analytical technique enables us to determine the extent of liquid-phase reactions without cleavage of the soluble matrix. The polymer matrix permitted us to obtain 1 H NMR spectra with a resolution comparable with that of spectra of the molecule in solution.


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