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Liquid crystallinity in collagen solutions and magnetic orientation of collagen fibrils

✍ Scribed by N. S. Murthy

Publisher
Wiley (John Wiley & Sons)
Year
1984
Tongue
English
Weight
414 KB
Volume
23
Category
Article
ISSN
0006-3525

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✦ Synopsis

Studies of the optical birefringence of solutions of acid-soluble collagen from rat-tail tendon a t 22Β°C in the pH range 1.0-6.0 show that collagen exhibits an isotropic to mesophase transition only between pH 2.4 and 3.0 a t 10% weight concentration. Such liquid crystalline order is probably essential for the orientation of collagen in a magnetic field. When solutions of neutral salt-soluble collagen were precipitated a t pH 7.0 by warming to 37Β°C ("heat gelling") in a magnetic field of ca. 20 kG, the resulting fibrils were oriented perpendicular to the direction of the field. Heat gelling is shown to be a useful technique for maintaining the orientation induced in precursor solutions even after the sample is removed from the magnetic field.

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