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Liquid Chromatography‐Electrospray Mass Spectrometry Determination of Imatinib and Its Main Metabolite, N ‐Desmethyl‐Imatinib in Human Plasma

✍ Scribed by Solassol, I.; Bressolle, F.; Philibert, L.; Charasson, V.; Astre, C.; Pinguet, F.

Book ID
118250106
Publisher
Taylor and Francis Group
Year
2006
Tongue
English
Weight
143 KB
Volume
29
Category
Article
ISSN
1082-6076

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## Abstract Besides affecting the systemic bioavailability of the parent drug, drug metabolizing enzymes (DMEs) may produce bioactive and/or toxic metabolites of clinical interest. We have investigated the capability to analyze simultaneously the parent drug and newly identified metabolites in pati