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Liquid chromatography tandem mass spectrometry method for the quantitation of NTBC (2-(nitro-4-trifluoromethylbenzoyl)1,3-cyclohexanedione) in plasma of tyrosinemia type 1 patients

✍ Scribed by Diran Herebian; Ute Spiekerkötter; Marc Lamshöft; Eva Thimm; Maurice Laryea; Ertan Mayatepek

Book ID: 108160993
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 471 KB
Volume: 877
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2009.03.014

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## Abstract A rapid and sensitive liquid chromatography/electrospray ionization tandem mass spectrometric (LC/ESI‐MS/MS) method has been developed to determine 1, 2‐[bis(1,2‐benzisoselenazolone‐3(2H)‐ketone)]‐ethane (BBSKE), a novel antineoplastic agent, in rat plasma. The analytes were separated o