𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Liquid chromatography and gas chromatography/mass spectrometry of lipoxygenase and cyclooxygenase products from platelets and endothelial cells

✍ Scribed by M. Guichardant; J. C. Bordet; M. Lagarde

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
295 KB
Volume
16
Category
Article
ISSN
1076-5174

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✦ Synopsis

Liquid chromatography coupled with mass spectrometry using either positive or negative ionization was used for measuring various lipoxygenase products of polyunsaturated fatty acids. The negative ionization appeared as the most sensitive mode and allowed to detect pmol amounts of products from biological extracts. Gas chromatographylmass spectrometry with the negative chemical ionization mode was also used for measuring prostacyclin synthetase products, namely the stable metabolites of PGI, , PGI, and dihomo PGI, . In this way, fmol amounts of metabolites could be measured in biological extracts.

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