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Liquid chromatographic determination of noxytiolin and 1-methyl-2-thiourea in serum: Application to pharmacokinetic studies in rabbits and humans

โœ Scribed by D. Debruyne; M. A. Moulin; H. Bricard; M.-C. Bigot

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
311 KB
Volume
74
Category
Article
ISSN
0022-3549

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A simple and sensitive reversed-phase liquid chromatographic method has been developed and validated for the analysis of nicardipine in human plasma and the study of the pharmacokinetics of the drug in human body. Nicardipine and nimodipine (internal standard) in plasma were extracted with hexane-bu