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Liquid Chromatographic determination of homovanillic acid, 5-hydroxyindoleacetic acid and probenecid levels in human cerebrospinal fluid during probenecid test

✍ Scribed by Marie-Claude Gagnieu; Véronique Menouni-Foray; Patrick Guardiola; Claude Quincy; Bernard Renaud

Book ID
115824713
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
859 KB
Volume
139
Category
Article
ISSN
0009-8981

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Determinations of 5-hydroxyindoleacetic
Determinations of 5-hydroxyindoleacetic acid and homovanillic acid in human CSF with monitoring of probenecid levels in CSF and plasma
✍ B.-M. Emanuelsson; E. Widerlöv; H. Walléus; L. K. Paalzow 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 634 KB

The accumulation of 5-HIAA and HVA in cerebrospinal fluid (CSF) was studied in eight healthy volunteers after oral administration of probenecid. Simulation indicated that a dose of 4.5 g probenecid should be used to achieve probenecid plasma concentrations between 200 and 400 pg/ml. Almost complete