High-performance liquid chromatographic
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F.A.L. Van Der Horst; J. Teeuwsen; J.J.M. Holthuis; U.A.Th. Brinkman
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Article
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1990
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Elsevier Science
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English
⚖ 364 KB
Cationic micelles have been used for the derivatization of the anti-Parkinson drug amantadine with the chromophore 1-fluoro-2,4-dinitrobenzene in urine. In the presence of 90 mM cetyltrimethylammonium bromide (CTAB), the conversion of amantadine into its derivative is complete within 4 min at 60 deg