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Lipoxygenase Inhibitors Abolish Proliferation of Human Pancreatic Cancer Cells

✍ Scribed by Xian-Zhong Ding; Patrick Iversen; Michael W. Cluck; Joseph A. Knezetic; Thomas E. Adrian

Book ID
115584116
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
192 KB
Volume
261
Category
Article
ISSN
0006-291X

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12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation
✍ Xian-Zhong Ding; Wei-Gang Tong; Thomas E. Adrian πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 203 KB

We previously reported that inhibition of the 12-lipoxygenase pathway abolished proliferation and induced apoptosis in several pancreatic cancer cell lines. Furthermore, the 12lipoxygenase product 12(S)-HETE stimulated pancreatic cancer cell proliferation and reversed 12-lipoxygenase inhibitorinduce