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Lipoxins Inhibit Akt/PKB Activation and Cell Cycle Progression in Human Mesangial Cells

✍ Scribed by Derick Mitchell; Karen Rodgers; Jennifer Hanly; Blaithin McMahon; Hugh R. Brady; Finian Martin; Catherine Godson


Book ID
117021524
Publisher
American Society for Investigative Pathology
Year
2004
Tongue
English
Weight
653 KB
Volume
164
Category
Article
ISSN
0002-9440

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## Abstract Glomerular mesangial cells both synthesize and respond to insulin‐like growth factor‐1 (IGF‐1). Increased activity of the IGF signaling pathway has been implicated as a major contributor to renal enlargement and subsequent development of diabetic nephropathy. Secreted protein acidic and