Liposomes composed of partially hydrogenated egg phosphatidylcholines: fatty acid composition, thermal phase behavior and oxidative stability
✍ Scribed by Johanna Lang; Carmen Vigo-Pelfrey; Francis Martin
- Book ID
- 103041590
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 593 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
Partially hydrogenated egg phosphatidylcholines (PHEPC) represent a new class of raw materials for liposome-based drug products. PHEPC were manufactured from native egg phosphatidylcholine (EPC) to iodine values (IV) 40, 30, 20, 10, and 1. Hydrogenation resulted in a complete loss of arachidonic acid (20:4) and docosahexaenoic acid (22:6) in IV 40 EPC and a progressive conversion of linoleic (18:2) and oleic acid (18:1) to stearic acid (18:0) at higher degrees of hydrogenation (IV 30, 20,10,1). Hydrogenation lead to formation of trans-fatty acid isomers maximally 18.5 mol% in IV 20 EPC. Liposom~s made from IV 20, IV 10 and IV 1 EPC had marked phase transitions between 20 and 6&C. PHEPC showed increased resistance to oxidation as measured by oxygen uptake during 2,2'-azobis-(2-amidinopropane) hydrochloride (AAPH) initiated accelerated oxidation. Various applications of these new materials in the manufacture of liposomes and liposome based drug products are discussed.