Liposome–DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma

Pegylated liposomal tumor necrosis facto

Pegylated liposomal tumor necrosis factor-α results in reduced toxicity and synergistic antitumor activity after systemic administration in combination with liposomal doxorubicin (Doxil®) in soft tissue sarcoma-bearing rats

✍ Timo L.M. ten Hagen; Ann L.B. Seynhaeve; Sandra T. van Tiel; Dirk J. Ruiter; Ale 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 337 KB

## Abstract Previously we reported that encapsulation of tumor necrosis factor‐α (TNF) in pegylated (STEALTH®) liposomes (TNF‐PEGL) dramatically improved circulation times of the protein and augmented accumulation in tumor tissue. We and others have demonstrated enhanced antitumor activity of doxor