Liposome fusion induced by pH-sensitive copolymer: Poly(4-vinylpyridine-co-N,N′-diethylaminoethyl methacrylate)
✍ Scribed by Jong-Sang Park; Yong-Beom Lim; Young-Min Kwon; Byeongmoon Jeong; Young Hun Choi; Sung Wan Kim
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 138 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0887-624X
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✦ Synopsis
Copolymers of 4-vinylpyridine (4VP) or N,NЈ-diethylaminoethyl methacrylate (DEAEMA) were synthesized with various comonomer feed ratios (30 : 70, 50 : 50, and 70 : 30). Charge densities along the polymeric chain were changed in a pHdependent manner. The copolymers induced membrane fusion of negatively charged liposomes followed by aggregation in a pH-dependent manner, which was investigated by resonance energy transfer. It was found that pH-dependent fusion of liposomes was dependent on the composition of 4VP and DEAEMA in the copolymer with the degree of protonation proportional to the difference in pK a value of the two monomers.