Liposome Destabilization by a 2,7-Diazapyrenium Derivative Through Formation of Transient Pores in the Lipid Bilayer
✍ Scribed by Romina Zappacosta; Monica Semeraro; Massimo Baroncini; Serena Silvi; Massimiliano Aschi; Alberto Credi; Antonella Fontana
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 335 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1613-6810
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The effect of the luminescent heteroaromatic electron acceptor N,N′‐dimethyl‐2,7‐diazapyrenium dichloride (DM‐DAP^2+^) on the stability of 1‐palmitoyl‐2‐oleoylphosphatydilcholine (POPC) liposomes is determined on the basis of the rate of release of different fluorescent probes entrapped within the liposome. The experiments show that DM‐DAP^2+^ exerts a substantial destabilizing action on the liposomal bilayer, particularly at low concentrations. Molecular dynamics simulations suggest that the activity of DM‐DAP^2+^ is related to its tendency to surround itself with water molecules, conceivably favoring the formation of transient pores across the bilayer.