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Liposome-bound cyclosporine: Retinal toxicity after intravitreal injection

✍ Scribed by Abdulrahman A. Alghadyan; Gholam A. Peyman; Bahram Khoobehi; Kwan-Rong Liu

Book ID
104636793
Publisher
Springer Netherlands
Year
1988
Tongue
English
Weight
214 KB
Volume
12
Category
Article
ISSN
0165-5701

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✦ Synopsis

The retinal toxicity of intraocular liposome-bound cyclosporine was studied in albino rabbits by means of electrophysiology and histopathology. During a followup period of one month, no histopathological or electroretinographic changes were noted using concentrations of 100, 200 and 500 micrograms injected intravitreally.

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Liposome-bound cyclosporine: Clearance a
Liposome-bound cyclosporine: Clearance after intravitreal injection
✍ Abdulrahman A. Alghadyan; Gholam A. Peyman; Bahram Khoobehi; Steve Milner; Kwan- πŸ“‚ Article πŸ“… 1988 πŸ› Springer Netherlands 🌐 English βš– 292 KB

The concentration of cyclosporine in the vitreous after intravitreal injection of 100 micrograms of either free or liposome-bound cyclosporine was studied in albino rabbits. We found that the half-life of free cyclosporine was about 6 hours and that of liposome-bound cyclosporine was about 3 days. T

Liposome-bound cyclosporine: Aqueous and
Liposome-bound cyclosporine: Aqueous and vitreous level after subconjunctival injection
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The concentration of cyclosporine in the aqueous and vitreous humors of albino rabbits was measured, using HPLC at intervals of 24, 48, 96, and 192 hours after subconjunctival injections of 2.5 mg of free or liposome-bound cyclosporine. The aqueous concentration was reasonably high in both groups un