Liposomal daunorubicin plasmatic and renal disposition in patients with acute leukemia
โ Scribed by Federico Pea; Domenico Russo; Mariagrazia Michieli; Massimo Baraldo; Anna Ermacora; Daniela Damiani; Michele Baccarani; Mario Furlanut
- Book ID
- 105993857
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 132 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0344-5704
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๐ SIMILAR VOLUMES
Leukemia cells isolated from eight patients with acute leukemia before treatment were examined for in vitro uptake of daunorubicin (DNR) and inhibition of DNA synthesis. In addition, plasma and cellular levels of DNR and daunorubicinol (DOL) were examined in six of the eight patients. Inhibition of
## Background: Liposomal encapsulation of daunorubicin (daunoxome, dnx; nexstar pharmaceutical, boulder, co) changes the pharmacology profile to increase delivery to tumor sites and decrease toxicity. the authors investigated the effect of daunorubicin in combination with ara-c in patients with ref