Liposomal Amphotericin B formulation and its pharmakokinetics in the treatment of fungal infections
β Scribed by Griese, M.
- Publisher
- Springer
- Year
- 1997
- Tongue
- German
- Weight
- 171 KB
- Volume
- 145
- Category
- Article
- ISSN
- 0026-9298
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## Abstract ## Background Invasive fungal disease is a major cause of death in immunocompromised patients. The filamentous fungus Scedosporium consists of two species, __S. prolificans__ and __S. apiospermum__, which can cause infections in immunocompromised patients that are often fatal. A signif
The efficacy and toxicity of free and liposome intercalated amphotericin-B (Amp-B) in controlling Aspergillosis, caused by Aspergillus fumigatus in BALB/c mice were studied. Liposomal Amp-B had higher LD50 (8.1 mg/kg) as compared to that of the free drug (1.2 mg/kg). An improvement in the therapeuti