## Background: Small cell carcinoma of the esophagus is a rare disease with aggressive behavior and poor prognosis. multidrug chemotherapy remains the treatment of choice given the systemic nature of the disease. radiotherapy has been used concurrently with chemotherapy to enhance local control. th
Liposarcoma of the head and neck: The University of Texas M. D. Anderson Cancer Center experience
β Scribed by Erica C. Davis; Matthew T. Ballo; Mario A. Luna; Shreyakumar R. Patel; Dianna B. Roberts; Xiaolin Nong; Erich M. Sturgis
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 182 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1043-3074
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Background.
Our aim was to review our experience with liposarcoma of the head and neck region.
Methods.
This is a retrospective case series at a comprehensive cancer center (1945β2005).
Results.
Of 30 patients, 10 (33%) were initially misdiagnosed. Local recurrences were common (overall rate = 53%), and 4 patients (13%) developed distant metastases. Decreased crude diseaseβspecific survival rates were significantly associated with recurrence (especially distant recurrence [0%]), age less than 38 years (40%), and pleomorphic subtype (45%); however, in KaplanβMeier analyses, only larger tumor size, negative margins, round cell subtype, and pleomorphic subtype were associated with significantly decreased diseaseβspecific survival (logβrank test p = .048, .041, .021, and .012, respectively).
Conclusions.
Based on this limited experience and existing literature, we continue to recommend surgery with negative margins as the treatment of choice and that adjuvant therapies should be considered in patients with highβgrade histology, large tumors, positive margins, or certain subsites. Β© 2008 Wiley Periodicals, Inc. Head Neck, 2009
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