Lipopolysaccharide-dependent enhancement of adherence-mediated chemiluminescence response of polymorphonuclear leukocytes

✍ Scribed by Dwenger, A. ;Schweitzer, Gertraud ;Funck, Monika

• Book ID: 101715191
• Publisher: John Wiley and Sons
• Year: 1988
• Weight: 359 KB
• Volume: 2
• Category: Article
• ISSN: 0884-3996
• DOI: 10.1002/bio.1170020107

✦ Synopsis

Adherence of resting polymorphonuclear leukocytes to nylon fibre increased the chemiluminescence response (CL) from 99400 to 910300 cpm/25000 PMNL. This effect could be amplified by lipopolysaccharide (LPS) priming of granulocytes in a dose-dependent fashion.

The results of nylon fibre adherence experiments suggest an in vitro model that might approximate certain conditions of in vivo PMNL-endothelial adherence and respiratory burst activation, and these reactions of polymorphonuclear leukocytes may contribute to the pathomechanisms of the Adult Respiratory Distress Syndrome.