Lipoplexes with alkylphospholipid as new helper lipid for efficient in vitro and in vivo gene transfer in tumor therapy

Aminoglycoside-derived cationic lipids a

Aminoglycoside-derived cationic lipids as efficient vectors for gene transfection in vitro and in vivo

✍ Philippe Belmont; Abderrahim Aissaoui; Michelle Hauchecorne; Noufissa Oudrhiri; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 138 KB

## Abstract ## Background Cationic lipids are at present very actively investigated for gene transfer studies and gene therapy applications. Basically, they rely on the formation of DNA/lipid aggregates via electrostatic interactions between their cationic headgroup and the negatively charged DNA.