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Lipophilic β-adrenoceptor antagonists stimulate cholesterol biosynthesis in human skin fibroblasts

✍ Scribed by Alberto Corsini; Franco Bernini; Giuliana Cighetti; Maurizio Soma; Giovanni Galli; Remo Fumagalli

Book ID
115779824
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
630 KB
Volume
36
Category
Article
ISSN
0006-2952

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In this report we showed that calmodulin antagonists chlorpromazine (CPZ) and W-7 (N-[6-aminohexyl]-5-chloro-l-naphtalenesulfonamide), when added to fibroblast cell cultures, gave rise to a time-and dosedependent decrease of sphingomyelinase activity. CPZ and W-7 also significantly inhibited LDL-and