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Lipophilic sulfophenylcarbocyanine dyes: Synthesis of a new class of fluorescent cell membrane probes

โœ Scribed by Wai-Yee Leung; Fei Mao; Richard P. Haugland; Dieter H. Klaubert

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
186 KB
Volume
6
Category
Article
ISSN
0960-894X

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โœฆ Synopsis

Almtraet: Two lipophilic sulfophenylcarbocyaulne dyes, 3 and 4, were synthesized as a new class of fluorescent cell membrane probes. Compared with other commonly used membrane probes, the new dyes have improved fluorescent quantum yield, retention in cell membranes and are easier to use in staining cells.

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โœ Jiong Chen; Armin Burghart; Chi-Wai Wan; Long Thai; Cesar Ortiz; Joe Reibenspies ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 167 KB

The 2-ketopyrrole complexes 3 and 4 were isolated as minor products in syntheses of the corresponding 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY ยฎ ) dyes 1 and 2. Compounds 4 were shown to be highly fluorescent having emissions between 504 and 544 nm with quantum yields between 0.52 and 0.89