✦ LIBER ✦

Lipofuscin distribution in the basal ganglia

✍ Scribed by Rudolf Altschul

Publisher: John Wiley and Sons
Year: 1943
Tongue: English
Weight: 1024 KB
Volume: 78
Category: Article
ISSN: 0021-9967
DOI: 10.1002/cne.900780104

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✦ Synopsis

The term wear-and-tear " pigment characterizes any special substance that is found in aging cells and increases slowly but steadily with age. The term is used without distinction whether the pigment is found in heart muscle, in suprarenal cortex, or in nerve cells and neuroglia. Yet in each of these different sites the pigment differs in its composition and nature from that found elsewhere-thus the wear-and-tear pigment of heart muscle consists mainly, if not completely, of hemofuscin, while the yellow pigment of nerve cells and neuroglia contains no hemofuscin or at any rate none can be demonstrated by the stain most commonly used, Mallory's basic fuchsin (Connor, '28). On the contraryi it is generally assumed that the lipofuscin of nerve tissue contains melanin or some closely related substance.

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