✦ LIBER ✦

Lipids, lipoproteins, and coronary heart disease: Implications for antihypertensive therapy

✍ Scribed by M. D. Feher; D. J. Betteridge

Publisher: Springer US
Year: 1989
Tongue: English
Weight: 628 KB
Volume: 3
Category: Article
ISSN: 0920-3206
DOI: 10.1007/bf00148479

No coin nor oath required. For personal study only.

✦ Synopsis

There is now considerable evidence that treatment of abnormalities of lipids and lipoproteins reduces the incidence of coronary heart disease (CHD). Treatment of hypertension, another major cardiovascular risk factor, has not been shown to have the same impact on CHD. Possible explanations for this are that cardiovascular risk factors may occur in combination in an individual or that therapy for hypertension has adversely affected one or several of the other risk factors for CHD, thereby offsetting the benefit gained by lowering blood pressure.

This article reviews the relationship between lipids, lipoproteins, and coronary heart disease, and the impact of cholesterol lowering on CHD. The evidence that antihypertensive drugs are associated with lipid and lipoprotein abnormalities is introduced by a critical appraisal of the several studies for such evidence. Implications for the treatment of the hypertensive patient are discussed.

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