Lipids and Atherosclerosis

✍ Scribed by Chris J. Packard (Author); Daniel J. Rader (Author)

• Publisher: CRC Press
• Year: 2005
• Leaves: 253
• Edition: 1
• Category: Library

✦ Synopsis

New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of s

✦ Table of Contents

List of contributors vii

Foreword xi

Preface xiii

Acknowledgements xiv

1. The assembly of very low density lipoproteins in the liver 1

S-O. Olofsson and L. Asp

2. Cardiovascular implications of partial, tissue-specific silencing of MTP 15

C.C. Shoulders

3. Acyl CoA: Diacylglycerol acyltransferases (DGATs) as therapeutic targets

for cardiovascular disease 31

J.S. Millar and J.T. Billheimer

4. The biochemical and physiological roles of ACAT1 and ACAT2 in

cholesterol homeostasis and atherosclerosis 41

R.G. Lee and L.L. Rudel

5. Overview of intestinal lipid metabolism 55

T.A. Miettinen and H. Gylling

6. The role of non-cholesterol sterols in the pathogenesis of atherosclerosis

and their modulation by the sitosterolaemia locus 63

E.L. Klett and S.B. Patel

7. FXR: the molecular link between bile acid and lipid metabolism 69

T. Claudel, E. Sturm, B. Staels and F. Kuipers

8. Overview of HDL and reverse cholesterol transport 81

P. Barter

9. LXR as a therapeutic target for atherosclerosis 93

I.G. Schulman and R.A. Heyman

10. Endothelial lipase and the regulation of HDL metabolism 101

K.O. Badellino and W. Jin

11. Cholesteryl ester transfer protein (CETP) inhibition as a therapeutic

strategy for raising HDL-cholesterol levels and reducing atherosclerosis 111

D.J. Rader

Contents

Prelims 14/7/05 4:44 pm Page v

12. Overview of insulin resistance and the metabolic syndrome 119

N. Sattar and B. Mukhopadhyay

13. Peroxisome proliferator activated receptors and energy metabolism 137

P. Gervois, J-C. Fruchart and B. Staels

14. Adipocytes and their secretory products 153

J.B. Prins

15. Regulation of adipocyte triglyceride storage 165

F. Karpe and G.D. Tan

16. Role of innate immunity in atherosclerosis: immune recognition,

immune activation and the atherosclerotic process 175

J-M. Fernández-Real

17. Role of CD44 in atherogenesis and its potential role as a therapeutic target 191

E. Puré

18. Lipoxygenases: potential therapeutic target in atherosclerosis 207

L. Zhao and C.D. Funk

19. Role of secretory phospholipase A2 isozymes (Lp-PLA2) 219

C.H. Macphee

Index

✦ Subjects

Bioscience;Biochemistry;Medicine, Dentistry, Nursing & Allied Health;Medicine;Pathology