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Lipid Rafts & Co.: An integrated model of membrane organization in T cell activation

✍ Scribed by Maximilan Zeyda; Thomas M. Stulnig


Book ID
116839036
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
445 KB
Volume
45
Category
Article
ISSN
0163-7827

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Raft microdomains have been shown to play a key role in T cell activation. We found that in human T lymphocytes the formation of functional rafts at the plasma membrane was induced by T cell priming. In resting T cells from peripheral blood Lck and the raft glycosphingolipid GM1 resided in intracell