Lipid Peroxidation in Photodynamically Stressed Mammalian Cells: Use of Cholesterol Hydroperoxides as Mechanistic Reporters

Phthalocyanine-sensitized lipid peroxida

Phthalocyanine-sensitized lipid peroxidation in cell membranes: Use of cholesterol and azide as probes of primary photochemistry

✍ Gary J. Bachowski; Ehud Ben-Hur; Albert W. Girotti 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 603 KB

Various phthalacyanine (Pc) derivatives of phototherapeutic interest have been shown to be efficient type II (singlet oxygen, 1O2) sensitizers in aqueous and non-aqueous solutions. However, primary Pc photochemistry in biological environments, e.g. cell membranes, has not been studied in a definitiv