Lipid peroxidation during the oxidation of haemoproteins by hydroperoxides. Relation to electronically excited state formation
✍ Scribed by Cadenas, Enrique
- Publisher
- John Wiley and Sons
- Year
- 1989
- Weight
- 860 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0884-3996
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✦ Synopsis
The formation of electronically excited states during hydroperoxide metabolism is analysed in terms of recombination reactions involving secondary peroxyl radicals and scission of the 0-0 bond of peroxides by haemoproteins, mainly myoglobin. Both processes may be sequentially interrelated, for the cleavage of H202 by metmyoglobin leads t o the formation of a strong oxidizing equivalent with the capability t o promote peroxidation of polyunsaturated fatty acids. The decomposition of lipid hydroperoxides by ferryl-hydroxo complexes, as that formed during the oxidation of metmyoglobin by H202, is a source of peroxyl radicals, the recombination of which proceeds with elimination of a conjugated triplet carbonyl or singlet oxygen.