Lipid peroxidation and protein thiol depletion are not involved in the cytotoxicity of N-hydroxy-2-acetylaminofluorene in isolated rat hepatocytes

The binding of reactive metabolites of t

The binding of reactive metabolites of the carcinogenN-hydroxy-2-acetylaminofluorene to DNA and protein in isolated rat liver nuclei: Effects of glutathione and methionine

✍ Meerman, John H. N. ;Tijdens, Roeline B. ;Mulder, Gerard J. 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 580 KB

The covalent binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated, intact rat liver nuclei was studied. The chemically synthesized 2-acetylaminofluorene-N-sulfate became covalently bound to DNA and protein to form adducts, 50% to 60% of whi