Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo

Quantitative determination of hydroxy fa

Quantitative determination of hydroxy fatty acids as an indicator of in vivo lipid peroxidation: Oxidation products of arachidonic and docosapentaenoic acids in rat liver after exposure to carbon tetrachloride

✍ David W. Thomas; Frederik J.G.M. van Kuijk; Robert J. Stephens 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 628 KB

An improved gas chromatography-mass spectrometry method has been applied to the quantitation of both in vitro and in vivo products of lipid peroxidation in rat liver stimulated with carbon tetrachloride. The method avoids problems of autoxidation of unsaturated fatty acids during sample preparation,