Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor

A physicochemical basis for the extensiv

A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs

✍ Shui-Mei Khoo; Richard J. Prankerd; Glenn A. Edwards; Christopher J.H. Porter; W 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB

The highly lipid soluble, free-base form of halofantrine (Hf base; $ 50 mg/ mL in triglyceride lipids), a highly lipophilic (calculated log P $ 8.5) antimalarial, has recently been shown to undergo signi®cant intestinal lymphatic transport (54% of administered dose) after postprandial administration