Lipase-mediated resolution of racemic 2-hydroxymethyl-1-methylthioferrocene
โ Scribed by Daniela Lambusta; Giovanni Nicolosi; Angela Patti; Mario Piattelli
- Book ID
- 103401969
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 182 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Racemic large secondary alcohol, 4 -hydroxyethyl-benzo-15-crown-5-ether, (ยฑ)-1 was kinetically resolved in high optical yield by asymmetric transformation with Candida antarctica lipase and Pseudomonas cepacia lipase.
Resolution of rac-flurbiprofen, 2-fluoro-0t-methyi-[1,1'-biphenyl]-4-scetic acid (1), by biocatalytic methodologies has been studied. Enzymatic hydrolysis of rac-flurbiprofen methyl ester (2) in aqueous-organic medium gave poor results. Transesterification of the same ester mediated by immobilized l