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Lipase-catalyzed transamidation of non-activated amides in organic solvent

โœ Scribed by Maria V. Sergeeva; Vadim V. Mozhaev; Joseph O. Rich; Yuri L. Khmelnitsky

Book ID
110226474
Publisher
Springer Netherlands
Year
2000
Tongue
English
Weight
39 KB
Volume
22
Category
Article
ISSN
0141-5492

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Exploration of lipase-catalyzed direct a
Exploration of lipase-catalyzed direct amidation of free carboxylic acids with ammonia in organic solvents
โœ Mike J.J. Litjens; Adrie J.J. Straathof; Jaap A. Jongejan; Joseph J. Heijnen ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 550 KB

Lipase-catalyzed direct amidation of free carboxylic acids is possible with ammonia in organic solvents. For butyric acid as a model compound the reaction proceeds well despite precipitation of ammonium butyrate, provided that the added molar amounts of butyric acid and ammonia are in the same range