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Lipase-catalyzed resolution of 1,3-dioxolane derivatives: synthesis of a homochiral intermediate for antifungal agents

✍ Scribed by Young Hee Kim; Chan Seong Cheong; So Ha Lee; Sook Jin Jun; Kwan Soo Kim; Hyun-Sung Cho


Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
264 KB
Volume
13
Category
Article
ISSN
0957-4166

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Lipase catalysed resolution of (R)- and
✍ Pietro Allevi; Pierangela Ciuffreda; Mario Anastasia πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 426 KB

Various (R)-and (S)-l-trimethylsilyl-l-alkyn-3-ols, chiral building units useful for the synthesis of biologically active compounds, have been efficiently resolved by enantioselective acetylation mediated by immobilized lipase PS. The resolution is applied to the synthesis of (R)-and (S)-5-octyl-2-(