Lipase-catalyzed monoprotection of 1,4-diols in an organic solvent using vinyl benzoate as acyl transfer agent

✍ Scribed by Pierangela Ciuffreda; Silvana Casati; Enzo Santaniello

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 101 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00694-4

✦ Synopsis

Lipase from Mucor miehei (MML) has been selected as the most suitable enzyme to catalyze the efficient monobenzoylation of 1,4-diols using vinyl benzoate as acyl transfer reagent in tert-butyl methyl ether. The regioselectivity of the monobenzoylation of 2-substituted-1,4-diols has been studied as well.