✦ LIBER ✦

Lipase-catalyzed irreversible transesterification using enol esters: Resolution of cyanohydrins and syntheses of ethyl (R)-2-hydroxy-4-phenylbutyrate and (S)-propranolol

✍ Scribed by Yi-Fong Wang; Shui-Tein Chen; Kevin K.-C. Liu; Chi-Huey Wong

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 253 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)99613-8

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✦ Synopsis

Procedures for the resolution of several cyanohydrins of synthetic value via lipase-catalyzed kinetic resolution using enol esters as irreversible transesterification reagents are developed and the syntheses of ethyl (R)-2-hydroxy-4-phenylbutyrate and (S)-propranolol from enantiomerically pure cyanohydrins are demonstrated.