A lipase-catalyzed enantioselective hydrolysis process under continuous in situ racemization of substrate by using trioctylamine as an organic base was developed for the production of (S)-naproxen from racemic naproxen thioesters in isooctane. Naproxen 2,2,2trifluoroethyl thioester and 45°C were sel
Lipase-catalyzed dynamic resolution of naproxen thioester by thiotransesterification in isooctane
✍ Scribed by Chun-Sheng Chang; Shau-Wei Tsai
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 131 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1369-703X
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## Abstract A lipase‐catalyzed enantioselective hydrolysis process under __in situ__ racemization of the remaining (__R__)‐thioetser substrate with trioctylamine as the catalyst was developed for the production of (__S__)‐fenoprofen from (__R,S__)‐fenoprofen 2,2,2‐trifluoroethyl thioester in isooct
In the enantioselective esterification of racemic Naproxen with trimethylsilyl methanol in isooctane by Candida cylindracea lipase, improvements in (S)-naproxen ester productivity and enzyme selectivity were demonstrated by adding bis(2-ethylhexyl) sodium sulfosuccinate (AOT) as the best surfactant.
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