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Lipase catalysed resolution of ferrocene cyanohydrin: access to novel ferrocenyl aminoalcohols and diamines

✍ Scribed by James A.S. Howell; Kristina Humphries; Patrick McArdle; Desmond Cunningham; Giovanni Nicolosi; Angela Patti; Martin A. Walsh

Book ID: 104361119
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 199 KB
Volume: 8
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(97)00092-x

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✦ Synopsis

R)-(+)-Ferrocene cyanohydrin acetate, obtained by enzymatic acylation of ferrocene cyanohydrin, may be transformed by reduction and alkylation into novel ferrocenyl I~-aminoalcohols. Substitution of acetate by methanolic HNMe2 proceeds with racemisation, but significant diastereoselection is observed on Strecker reaction using (-)-PhCH(Me)NHMe. (~ 1997 Elsevier Science Ltd

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