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Linoleic acid metabolites act to increase contractility in isolated rat heart

✍ Scribed by Lex A. Mitchell; David F. Grant; Russell B. Melchert; Nathan M. Petty; Richard H. Kennedy


Book ID
107567429
Publisher
Humana Press Inc
Year
2002
Tongue
English
Weight
173 KB
Volume
2
Category
Article
ISSN
1530-7905

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Dose-dependent pharmacokinetics of toxic
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## Abstract It has been reported that urinary excretion of two metabolites of valproic acid (VPA), 4‐ene‐valproic acid (4‐VPA) and 2,4‐diene‐valproic acid (2,4‐VPA), increased exponentially with the administration of high doses of VPA, and this increased formation of toxic metabolites could be rela