Linker histones versus HMG1/2: a struggle for dominance?
✍ Scribed by Jordanka Zlatanova; Kensal van Holde
- Book ID
- 101303909
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 115 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0265-9247
No coin nor oath required. For personal study only.
✦ Synopsis
The linker histones (H1, H1 zero, H5, etc.) and a group of abundant non-histone chromosomal proteins (HMG1/2) bind to linker DNA in chromatin and exhibit both generalized and specific effects on gene transcription. The two classes of proteins share many features of DNA binding behaviour, although they are structurally unrelated. While the linker histones and HMG1/2 exhibit direct competition in binding to such structures as four-way junction DNA, whether they compete for binding to the nucleosome has not been investigated. The possibility for either opposite or synergistic effects on gene regulation must be considered at this point.