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Linkage studies in X-linked Alport's syndrome

✍ Scribed by S. Szpiro-Tapia; G. Bobrie; M. Guilloud-Bataille; S. Heuertz; C. Julier; J. Frézal; J. P. Grünfeld; M. C. Hors-Cayla

Publisher
Springer
Year
1988
Tongue
English
Weight
292 KB
Volume
81
Category
Article
ISSN
0340-6717

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✦ Synopsis

Four kindreds segregating for Alport's syndrome (ASLN) compatible with a X-linked inheritance were studied for linkage with polymorphic markers of the human X chromosome. No recombinant was observed between the ASLN locus and the DXS101 and DXS94 loci, the maximum lod scores were z = 3.93 and 3.50 respectively. Linkage data between the ASLN locus and the other genetic markers used in the present study are in keeping with the assignment of the mutation to the proximal Xq arm.

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