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Linkage ofPgm-3in the house mouse and homologies of three phosphoglucomutase loci in mouse and man

✍ Scribed by J. H. Nadeau; J. Kömpf; G. Siebert; B. A. Taylor

Publisher
Springer
Year
1981
Tongue
English
Weight
497 KB
Volume
19
Category
Article
ISSN
0006-2928

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✦ Synopsis

The discovery of a third phosphoglucomutase locus in the house mouse is reported. Three alleles are recognized on the basis of differences in electrophoretic mobility and enzymatic activity. Pgm-3 a (fast mobility and high activity) is present in inbred strain C57BL/lOJ and 24 other strains; Pgm-3 b (slow mobility and high activity) is present in LP/Pas and six other strains; and Pgm-3 c (no detectable activity in any tissue tested) is present in strain DBA/2J and 14 other strains. Seventy-four recombinant inbred strains derived from progenitors that differed at Pgrn-3 were used to study genic linkage. Pgm-3 is on chromosome 9 and is linked to Sep-1, d, Mod-1, and Ltw-3. Gene order and recombination frequencies are estimated as d 3.8 +_ 1.8% Pgm-3 2.3 +_ 1.2% Mod-1. Substrate specificities and cofactor requirements show that mouse Pgm-1 is homologous with human Pgm-2, mouse Pgm-2 with human Pgm-1, and mouse Pgm-3 with human Pgm-3.

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