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Linkage of the grey coat colour locus to microsatellites on horse chromosome 25

✍ Scribed by M. M. Locke; M. C. T. Penedo; S. J. Bricker; L. V. Millon; J. D. Murray

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
129 KB
Volume
33
Category
Article
ISSN
0268-9146

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✦ Synopsis

The progressive loss of colour in the hair of grey horses is controlled by a dominantly inherited allele at the Grey locus (G^G^). In this study, two paternal Quarter Horse (QH) families segregating for the G^G^ allele were genotyped with a set of 101 microsatellite markers spanning the 31 autosomes and the X chromosome. This genome scan demonstrated linkage of Grey to COR018 (RF=0.02, LOD=12.04) on horse chromosome 25 (ECA25). Further chromosome‐specific analysis of seven total QH families confirmed the linkage of Grey to a group of ECA25 markers and the map order of NVHEQ43‐(0.24)‐UCDEQ405‐(0.09)‐COR080‐(0.05)‐GREY‐(0.14)‐UCDEQ464 was produced. Although G was found to be linked to TXN and COR018 in the chromosome‐specific analysis, the data were not sufficiently informative to place either marker on our ECA25 map with significant LODs. Our results excluded the equine tyrosinase related protein 1 (TYRP1) and melanocyte protein 17 (Pmel17) genes as possible candidates for the grey phenotype in horses.

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✍ J. E. Swinburne; A. Hopkins; M. M. Binns 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 255 KB

The dominant grey coat colour gene of horses has been mapped using a whole genome scanning approach. Samples from a large half‐sibling pedigree of Thoroughbred horses were utilized in order to map the grey coat colour locus, __G__. Multiplex groups of microsatellite markers were developed and used t